San Antonio (20-11) suffered a rare home loss, falling 100-98 to Milwaukee on Tuesday. That snapped a five-game winning streak for the Spurs, who also have winning stretches of four and six in a row since Nov. 21.

Now, the Spurs look to regroup against Memphis (10-22), which has lost three in a row overall and four straight to San Antonio, including all three meetings this season. The Spurs won 106-103 in double overtime over the Grizzlies last Saturday.

"Memphis is a young, athletic, deep team," said Spurs coach Gregg Popovich, whose team looks to sweep the season series with the Grizzlies for the eighth time and third since the team relocated from Vancouver in 2001. "They play everybody tough."

Tim Duncan, shooting 50.9 percent this season, scored 22 points but was 7-for-20 from the field and missed a layup with 3.8 seconds to go versus Milwaukee for San Antonio's third loss in 14 games.

"We lost the game before that," Spurs guard Roger Mason said. "We lost the game the first two quarters when they outhustled us."

Michael Finley had 20 points and Tony Parker added 19 with 10 assists for San Antonio, which allowed the Bucks to shoot 51.3 percent while giving up 100 points in regulation for just the fifth time this season.

"It was a lot of missed assignments," Popovich said of the Spurs, who are second in the Western Conference allowing 93.8 points per contest. "They played sharper and were more aggressive than we were."

Popovich hopes to see a better effort as the Spurs look to improve their 20-7 road mark against the Grizzlies. San Antonio is averaging 103.0 points overall against Memphis this season.

Parker is averaging 23.5 points and 6.0 assists in two games versus the Grizzlies in 2008-09, and had 32 in the most recent meeting. Duncan had 29 on 11-for-19 shooting in the same game.

Memphis' standout rookie O.J. Mayo scored 29 points in that contest and is averaging the same while shooting 35-for-63 in the three games versus the Spurs this season.

Mayo, though, looks to bounce back from his most recent outing where he scored 12 points on 4-for-20 shooting in a 101-89 home loss to Phoenix on Tuesday.

The Grizzlies led by eight heading into the fourth quarter, but hit three of 18 shots and were outscored 31-11. Mayo missed his last 13 shots for Memphis, which shot 38.7 percent for the game.

"I just think that maybe you could say there's less oxygen going to the brain, I don't know," Memphis coach Marc Iavaroni said of his team's continued late-game troubles. "We certainly don't play the same way. I think we start to press, start to hold and we start to dribble around. We start to feel footsteps. Until we get that out of our heads, that's not going to change."

Memphis has lost seven of eight overall since winning four in a row.